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Drug interactions and pharmacokinetics news

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Drug interactions and pharmacokinetics
Varying efficacy of HIV drug cocktails explained

A new mathematical model of HIV-fighting drugs reveals the biology beneath the varying success of such treatments. 

Published
13 July 2011
From
Science News
Neurological and cognitive problems
HIV disrupts blood-brain barrier: Cellular study suggests way virus may cause neurological deficits

HIV weakens the blood-brain barrier by overtaking a small group of supporting brain cells, according to a new study. The findings may help explain why some people living with HIV experience neurological complications, despite the benefits of modern drug regimens.

Published
28 June 2011
From
Science Daily
Drug interactions and pharmacokinetics
Certain Anti-Seizure Drugs Up the Risk of HIV Treatment Failure

People taking older anti-seizure medications that are broken down by the same liver enzyme (CYP3A4) as many common antiretroviral (ARV) drugs were more likely to experience treatment failure than people taking seizure medications that aren’t broken down by that liver enzyme.

Published
14 June 2011
From
AIDSMeds
Cancer
First Test of New Cancer Drug in People With HIV Is Promising

A newer cancer drug, Sutent (sunitinib), is tolerable when paired with at least some antiretroviral (ARV) drugs in people with HIV.

Published
06 June 2011
From
AIDSMeds.com
Tuberculosis and HIV
New findings on drug tolerance in TB suggest ideas for shorter cures

A study of host-pathogen responses in tuberculosis elucidates molecular mechanisms of antibiotic tolerance in tuberculosis and further suggests a strategy for shortening curative therapy (currently six months) using a class of drugs -- efflux pump inhibitors-- that are already approved for treating high blood pressure and angina, and available for use in people.

Published
03 March 2011
From
Eurekalert Inf Dis
Drug interactions and pharmacokinetics
Study to analyze seizures in HIV patients, explore drug interactions

A Michigan State University researcher is looking to uncover the risks of treating seizures in HIV-positive patients, providing much-needed data on possible interactions between antiepileptic drugs and antiretroviral medicines that potentially could make HIV drugs less effective or the disease itself drug resistant.

Published
22 February 2011
From
Eurekalert Inf Dis
Drug interactions and pharmacokinetics
Drug Interaction iPhone app: review

Thanks to The University of Liverpool, checking to see how a drug you have just been prescribed or are about to buy over the counter  might interact with your HIV meds has just become a lot easier:  with the HIV iChart app developed for the iPhone and iPod.

Published
11 November 2010
From
Positive Pulse
People who inject drugs
Call to change methadone use law

The Royal Pharmaceutical Society says pharmacists should have more control over doses of methadone given out.

Published
07 October 2010
From
BBC Health
Drug interactions and pharmacokinetics
Raltegravir Pharmacokinetics Disrupted by Antacids in Healthy Patients With HIV: Presented at ICAAC

If individuals with HIV ingest common over-the-counter antacids at the same as taking raltegravir, there may be changes in the pharmacokinetics of the antiretroviral drug.

Published
16 September 2010
From
Doctor's Guide
Drug interactions and pharmacokinetics
IAC: Smoking Has No Impact on Atazanavir Levels

Cigarette smoking by patients infected with human immunodeficiency virus (HIV) does not appear to impact therapeutic levels of the protease inhibitor atazanavir (Reyataz), researchers said here at the 2010 International AIDS Conference.

Published
22 July 2010
From
MedPage Today
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Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.